Digital I/O LLC provides services to over 250 active clients, including:
- Agencia Pérez Ortíz
- Baja Freight
- Berry Plastics
- Caliente
- Certona Corporation
- Chula Vista School District
- City of Coronado
- County of Imperial
- EcoGas (Distribuidora de Gas Natural) 3 locations
- Firewire Surfboards (U.S., AU & Taiwan)
- Four Seasons Design (San Diego, Tecate Mexico)
- Frontera & La Cronica – leading newspapers in N.W. Mexico
- Grupo Logix
- Image Duty Free
- Internet Crusade
- ISE Corporation
- ITW SpaceBag
- Keils Markets (2 locations)
- Life Settlement Solutions
- Multiflora
- Neighborhood National Bank
- North American Productions Systems (2 locations)
- Obras y Desarollos URBI (72 locations)
- Pacific West Builders (San Diego & Guam)
- Pettit Kohn Ingrassia & Lutz (2 locations)
- Sempra Energy Global
- Sempra Pipelines (7 locations)
- Southwestern Community College (3 locations)
- Stedman & Dyson Structural Engineers
- Time Warner Cable
- TYCO Electronics, Adhesives & Healthcare
- US Border Patrol
- US Department of Homeland Security
- US Navy
- Veolia Water
- Vistaflor Corporation (Miami & Bogotá)
- Western Cancer Centers (Radiation Medical Group) 7 locations
- Zoom Telephonics

